Hypertriglyceridaemia in Schnauzers unresponsive to diet
8-year-old Miniature Schnauzer with primary hypertriglyceridaemia (secondary causes ruled out). After 3 months of a well-followed very low-fat diet without fatty treats, fasting triglycerides remain high.
| Parameter | Result | Reference |
|---|---|---|
| Triglycerides (baseline) | 1,150 mg/dL | 20–150 |
| Triglycerides (3 months of diet) | 650 mg/dL | 20–150 |
| Cholesterol | 310 mg/dL | 130–300 |
What is most appropriate now?
chevron_right Show answer and explanation
A. Accepting the result: below 1,000 mg/dL there is no risk
Persistent concentrations above about 500 mg/dL are associated with pancreatitis and other complications. The usual goal is to keep them below that value.
B. Continuing the diet and adding fish oil omega-3 fatty acids and/or a fibrate, monitoring liver enzymes and CK
Correct. When diet alone is not enough, omega-3s and fibrates (bezafibrate, fenofibrate) effectively lower triglycerides. They are usually well tolerated, but possible increases in liver enzymes and CK should be monitored.
C. Atorvastatin as first-choice drug
Statins act mainly on cholesterol and have less effect on triglycerides. Omega-3s and fibrates are preferred for hypertriglyceridaemia.
D. Returning to the previous diet, since the low-fat diet has not worked
The diet has nearly halved the triglycerides; it is the foundation of treatment, and stopping it would make them soar again. What is needed is to add to it.
lightbulb Key takeaway
Before diagnosing primary hyperlipidaemia, rule out secondary causes: hypothyroidism, Cushing's, diabetes, protein-losing nephropathy, cholestasis and obesity. In Miniature Schnauzers, primary hypertriglyceridaemia is associated with pancreatitis, gallbladder mucocele, proteinuria and insulin resistance: it deserves treatment to target.
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Updated: October 31, 2026 · Educational content for veterinary professionals. It does not replace current clinical guidelines or the judgement of the attending veterinarian.